Guys and gals out there. I just got this game and had some major issues in that I couldn't watch the cutscenes without wanting to rip out my hair and I have no audio in game. I had a weird feeling that nothing was wrong and after digging around online for a while, I found no help. Now... I didn't find this forum before figuring out my fix so it might be on here somewhere, either way here goes. Mind you, this is for the Steam version: Turn off "Enable Fullscreen Effects" in the settings options before loading the game (it's the option for setup when you launch from Steam) and voila! Smooth sailing from there on out.
I hope this helps someone, if so, go hug someone. Or not, I don't really care.